Kynurenic acid protects against gastroduodenal ulceration in mice injected with extracts from poisonous atlantic shellfish
Identifieur interne : 004A61 ( Main/Exploration ); précédent : 004A60; suivant : 004A62Kynurenic acid protects against gastroduodenal ulceration in mice injected with extracts from poisonous atlantic shellfish
Auteurs : Gary B. Glavin [Canada] ; Ranjan Bose [Canada] ; Carl Pinsky [Canada]Source :
- Progress in Neuropsychopharmacology & Biological Psychiatry [ 0278-5846 ] ; 1989.
Abstract
1. Mice were treated with an extract prepared from poisonous Atlantic mussels.2. Gastric and duodenal ulcers, duodenal hyperemia and peritoneal ascites resulted from administration of the shellfish extract, with an LD84 of 1.0 ml.3. Kynurenic acid, an antagonist at excitatory amino acid receptors, protected significantly against gastroduodenal ulcers, ascites and hyperemia when given at 60 or 75 min post-extract.4. It is likely that the gastrointestinal damage evoked by this extract is due to its domoic acid content and that kynurenic acid may prove useful against domoic acidinduced gastropathy.
Url:
DOI: 10.1016/0278-5846(89)90148-6
Affiliations:
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Glavin</name></author><author><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name></author><author><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E97DBAE1718495E80C793E038D3975C7FE646F7</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1016/0278-5846(89)90148-6</idno><idno type="url">https://api-v5.istex.fr/document/1E97DBAE1718495E80C793E038D3975C7FE646F7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001342</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001342</idno><idno type="wicri:Area/Istex/Curation">001342</idno><idno type="wicri:Area/Istex/Checkpoint">002161</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002161</idno><idno type="wicri:doubleKey">0278-5846:1989:Glavin G:kynurenic:acid:protects</idno><idno type="wicri:Area/Main/Merge">005412</idno><idno type="wicri:Area/Main/Curation">004A61</idno><idno type="wicri:Area/Main/Exploration">004A61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Kynurenic acid protects against gastroduodenal ulceration in mice injected with extracts from poisonous atlantic shellfish</title><author><name sortKey="Glavin, Gary B" sort="Glavin, Gary B" uniqKey="Glavin G" first="Gary B." last="Glavin">Gary B. Glavin</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Inquires and reprint requests should be addressed to: Dr. Gary B. Glavin, Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, 770 Bannatyne Avenue, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics Winnipeg</wicri:regionArea></affiliation></author><author><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics Winnipeg</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Neuropsychopharmacology & Biological Psychiatry</title><title level="j" type="abbrev">PNP</title><idno type="ISSN">0278-5846</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="569">569</biblScope><biblScope unit="page" to="572">572</biblScope></imprint><idno type="ISSN">0278-5846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Mice were treated with an extract prepared from poisonous Atlantic mussels.2. Gastric and duodenal ulcers, duodenal hyperemia and peritoneal ascites resulted from administration of the shellfish extract, with an LD84 of 1.0 ml.3. Kynurenic acid, an antagonist at excitatory amino acid receptors, protected significantly against gastroduodenal ulcers, ascites and hyperemia when given at 60 or 75 min post-extract.4. It is likely that the gastrointestinal damage evoked by this extract is due to its domoic acid content and that kynurenic acid may prove useful against domoic acidinduced gastropathy.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="Glavin, Gary B" sort="Glavin, Gary B" uniqKey="Glavin G" first="Gary B." last="Glavin">Gary B. Glavin</name></region><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name><name sortKey="Glavin, Gary B" sort="Glavin, Gary B" uniqKey="Glavin G" first="Gary B." last="Glavin">Gary B. Glavin</name><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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